SLEDAI-2K (Systemic Lupus Erythematosus Disease Activity Index)
Rheumatology specialty tool
Bedside Tool Interface Configuration
Predicts current disease activity in Systemic Lupus Erythematosus (SLE) based on objective physiological signs across major organs within the last 10 days.
Algorithm Checklist Parameters:
- Neurological (Seizure, Psychosis, Organic brain syndrome, Cranial neuropathy, or severe Lupus Headache) (+8 Pts)
- Vasculitis (ulceration, gangrene, tender nodules, periungual infarcts) (+8 Pts)
- Arthritis (active pain/synovitis in ≥ 2 joints with effusion) (+4 Pts)
- Renal (granular/RBC casts, Hematuria, Pyuria, or Proteinuria >0.5g/24h) (+4 Pts)
- Mucocutaneous (Active inflammatory malar/discoid rash, alopecia, or oral ulcers) (+2 Pts)
- Pleurisy or Pericarditis (pleuritic rub/effusion/chest pain) (+2 Pts)
- Immunology (Low complement C3/C4 or high anti-dsDNA bindings) (+2 Pts)
- Active Fever (> 38°C / 100.4°F) (+1 Point)
- Cytopenia (Thrombocytopenia <100k or Leukopenia <3k) (+1 Point)
Primary Clinical Application:
Provides crucial, structured evidence of SLE disease control to justify biological modifying therapies.